They include increased inflammation in the body, hypoglycemia, headache, cognitive impairment, fatigue, and possible arthritis. The choice about which to take is really up to you and your healthcare provider. Anxiety and depression can be triggered by a range of hormonal responses. You are likely looking for solutions to improve your mental clarity and the health of your NeuroEndoMetabolic (NEM) Stress Response. Phosphatidylserine is thought to play a role in helping to regulate mood. Phosphatidylserine’s greatest benefit is its ability to lower cortisol levels by optimizing the brain’s relationship with the adrenal glands. In addition, PS is very beneficial for your brain, but it works on the peripheral nervous … The results appeared to indicate that the combination resulted in significantly less intestinal bleeding and GI damage while maintaining naproxen’s anti-inflammatory activity. If PC can prevent liver damage, it could have a great impact on the entire NEM system. When used properly it can mitigate GI injury through anti-inflammatory actions. Because PS can stimulate serotonin production, it can pacify this stress response circuit. If you are looking to improve the health of your NEM stress response, both of these supplements are a good place to look. Though this hormone is an essential part of survival, constant stress can cause an overabundance of cortisol in the body. Many people find they need less antidepressant medications when they use PS in conjunction with their medication. But in modern society, our bodies may often feel the need to respond to danger. There is another form of serine known as phosphorylated serine. If you are still interested in trying phosphatidyl serine read on and I will give you the information you need to choose the right supplement. It specifically affects the levels of cortisol as well, which is an important hormone produced by the adrenal gland. CONTACT US| So how does phosphatidyl choline play into that process? Sounds good, doesn't it? The rate-limiting step in the body's production of phosphatidyl serine is the phosphorylation of serine. Anxiety is mainly caused by the NEM system's response to fear. This, however, is not entirely conclusive. Role of phosphatidylserine … Furthermore, this phospholipid’s ability to maintain healthy cortisol levels may have the biggest impact overall on the hormonal stress response, and of course the adrenals themselves. These same effects may even aid in weight loss when weight gain is caused by cortisol imbalance. Fatty acids and glycerol are available in abundance from body fat and from dietary sources. My advice to any athlete considering phosphorylated serine supplementation is to have a salivary cortisol analysis performed. Mol Biol Cell. The adrenal glands produce hormones designed to make us escape danger. PS had been found by many to relieve stress and the symptom of anxiety. In a 2015 study published in Mental Illness, for instance, people over the age of 65 with major depression took a supplement containing phosphatidylserine and the omega-3 fatty acids DHA and EPA three times daily for 12 weeks. It found that I had low DHEA levels and high cortisol levels. What are the consequences? Kim HY, Akbar M, Lau A, Edsall L. Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3). I'll research the Isocort...what is in that anyway? Phosphatidyl Choline or (PC) is a phospholipid which is attached to a choline particle. The NEM network is broken up into six major circuits which include: the metabolic, cardionomic, hormonal, cardionomic, inflammation, and neuroaffect networks. This may even help to alleviate the symptoms of anxiety. I first started treatment with phosphatidyl serine. Serotonin is a hormone that can improve this circuits health and as a result, our mood and feelings. Phosphorylated serine is able to act quicker in the body and typically more affordable as well. But what is the difference between them? So as you can imagine this supplement can have a tremendous effect on the neuroaffect circuit of the NEM stress response. You may have noticed that the title of the article referred to phosphorylated serine but all along I have been discussing phosphatidyl serine. Seriphos) 2) have a much stronger cortisol-lowering impact. When the body needs phosphatidyl serine, it adds fatty acids and glycerol to the phosphorylated serine. Here's why: Phosphatidyl serine is a phospholipid composed of one glycerol, two fatty acid, and one phosphorylated serine molecules. Back to top #12 pinballwizard Life Member; 317 posts 4 ₮ Posted 10 December 2004 - 06:09 AM. It may be preventative for many forms of toxicity and liver disease. Because PS helps correct this imbalance by balancing cortisol levels in the body, it may actually alleviate anxiety. Otherwise, you may be playing with fire. Vibrant COVID-19 Immunecheck - My top choice for coronavirus antibody tests. Fatty acids and glycerol are available in abundance from body fat and from dietary sources. PS can have the effect of calming the neuroaffect and hormonal circuits of the NEM stress response. PC has effects that possibly enable it to pacify the inflammation and metabolic stress response circuits of the NEM stress response. This compound acts as a necessary component in each and every cell of the human body. NAC is being studied in COVID-19. These finely balanced circuits rely on one another to function as a healthy whole. Adrenal Fatigue Syndrome or (AFS) occurs when too much work has been required of the adrenal glands over long periods of time. I think I've found the difference between the two serines...the phosphylated serine already has two main components broken down already and made more available to the body vs the 'tydal serine. Just wanted to put in my two cents when it comes to phosphorylated serine. Dr. Joseph A. Debé graduated from the Southern California University of Health Sciences in 1986. The NeuroEndoMetabolic (NEM) Stress Response is a unique way at looking at your bodies’ health. If both your inflammation circuit and neuroaffect, or your metabolic and neuroaffect are being triggered for example, maybe a combination of the two would suit you. Moreover, it is important for brain development and metabolism. MAKE AN APPOINTMENT. Serotonin production is linked to mental health and wellbeing. After only ten days of high doses … Inflammation causes further irritation and can make things worse, and eventually triggers other stress response circuits, which cause the adrenal glands to pump out cortisol and adrenaline. Both P. Serine and P. choline are excellent supplements. Your neuroaffect response is then activated, and the cycle goes on and on. Summary – L-serine vs Phosphatidylserine. That is where PC may come into play. Some studies have even shown PC could also have protective, and even has healing effects on patients that have hepatitis A, B or C. One such study was published in the journal Liver. Though it resembles the head piece, phosph orylated serine is different —it is not a phospholipid and does not work like PS does. How about some Lime with that Coronavirus? Fatty acids and glycerol are available in abundance from body fat and from dietary sources. They have benefits for many people that have been afflicted with AFS and may serve to balance your metabolic, inflammatory, hormonal and neuroaffect circuits, of the NEM stress response. Is phosphatidyl choline all it is made out to be. If, however, your neuroaffect is being triggered by inflammation or metabolic circuits, PS may not have much of an effect overall. I'm going to take a mix of Phosphatidylserine and Bacopa right now! There is another form of serine known as phosphorylated serine. It is important to address AFS early, or the results could get worse. Purchase Phosphorylated Serine (Seriphos), (516) 829-1515 L-serine is a nonessential amino acid that is essential for the synthesis of proteins, nucleotides, neurotransmitters, and lipids. When the body needs phosphatidyl serine, it adds fatty acids and glycerol to the phosphorylated serine. The proper function of all 6 circuits manifests itself as a healthy body. If the emerging research surrounding PC turns out to be accurate, it can mean that PC can actually prevent inflammation parts of the body. 2012 Jun;23(11):2198-212. It is present in every cell of the body. Emerging studies hinted that PC might actually protect the intestinal lining and the stomach from the damaging effects that are often caused by using non-steroidal anti-inflammatory drugs (NSAID). When one consumes phosphatidyl serine, the digestive process cleaves the glycerol and fatty acids from the phosphorylated serine before it is absorbed. A second study from the journal Alcoholism: Clinical and Experimental Research, showed the use of PC resulted in the protection of rat liver cells from toxicity caused by alcohol.

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